MORE研究所科研动态

2024 10/24

HSP90 Complex From OLP Lesion Induces T‐Cell Polarization via Activation of Dendritic Cells
HSP90 complex isolated from OLP lesion activated TLR9/IFN- α of DCs and further promoted the polarization of naïve T cells toward Th17 immunity.【详细】
2024 08/13

Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects
This study provided new insights into mammalian embryonic development and will help understand the pathology of congenital birth defects in humans. In addition, it expanded our understanding of the etiology of obesity.【详细】
2024 06/25

Gestational diabetes mellitus induces congenital anomalies of the kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
The expression of Ret and downstream p-ERK activity were enhanced in UBs, which indicated the alteration of RET/MAPK/ERK pathway may be one of the mechanisms contributing to the increased occurrence of CAKUT associated with GDM. 【详细】
2024 04/24

GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract
Point-mutant mouse strains were constructed (Gen1: c.1068 + 3 A > G, p.R400X, and p.T105R) based on the variant frequency in the CAKUT group and functional impairment in vitro study and CAKUT phenotypes were replicated in each. Conclusion Overall, our findings indicated GEN1 as a risk factor for human CAKUT.【详细】
2023 09/01

ARF1 maintains intestinal homeostasis by modulating gut microbiota and stem cell function
ARF1 was essential for ISC proliferation and differentiation. Loss of ARF1 increased susceptibility to DSS-induced colitis and gut microbial dysbiosis. Gut microbiota depletion by antibiotics could rescue the in-testinal abnormalities to a certain extent. Furthermore, RNA-seq analysis revealed alterations in multiple metabolic pathways. 【详细】